Greetings fellow adventurers,

    Senolytics are arguably the best rejuvenation therapy currently available, and though costly, FOXO4-DRI is the most effective senolytic.
   This site is a repository for the first human experiences with this exciting new substance. And, though anecdotal, the hope is this information will prove valuable to early adopters and science1.

    I’ve been experimenting with longevity supplements/therapies for years and have seen little effect, but an exception popped up in January 2017. While experimenting with the senolytic compounds Dasitinib and Quercetin, I experienced a significant jump in my cardiovascular endurance2. My treadmill running time went from 5mins to 6mins (still nothing to write home about) and it then stabilized at about 4.5mins. If I can repeat this temporary increase with FOXO4-DRI, it would hint at efficacy. But I experienced serious side effects with Dasitinib. It felt like a bad flu. My heart raced, got chills and sweats; and when we checked my blood pressure, systolic was 186!

Summary Round #2

Encouraging results! I am 52 next month. After my first round of FOX04-DRI my Bio-age(DNA Methylation) was 47.5yrs. And after my second round my Bio-age is 46.8. Of course they […]

Update Round #2

I’m a few weeks into Round#2 {I started and then stopped because I missed a couple of dosages with travelling etc}, anyway, everything is fine. Because of the reaction I […]

Summary- Round #1

Results so far: 1. Feeling great (though, ignoring minor aches, I did before). 2. Change in sleep patterns- Experiencing a strange side-effect where I wake up super early- and am WIDE awake […]

Pls add your experiences with Senolytics here: 12

Took a 50unit shot (approx. 60mg). Tread Mill = 5.5 mins

Boosting the concentration of FOXO4-DRI. Added 30mg more to the vial. Injected .3ml into fat. Here’s the hair today– feels thicker and looks much better than the last pic from […]

Still feel great, lots of energy. Tread Mill = 4.75 mins

Tread Mill = 5.5 mins Woohoo! still improving.

30units of FOXO4-DRI on insulin syringe.

Wide awake at 4am. Weird side-effect, I apparently need less sleep and have more energy. Injected another 50mg subcutaneously in morning.