Latest updates/Summary

  1. The Belgian longevity documentary just came out! here’s the clip on FOX04-dri and my protocol.
  2. Latest mDNA analysis of my biological age showed 48yrs woohoo!- but a telomere analysis on that same date showed 54.4 years old. (Orange line is the bio age)
  3. I received a stem cell treatment recently–I’m hoping to improve my thyroid auto-immune issue– will retest markers in about five months.
  4. Need an intern-type to help with a mouse lifespan study in Scottsdale– pls contact me if interested.


Also, been working on my ‘Optimal Longevity Protocol’ –It is available online at


  1. Hi – good to see that documentary clip! Regarding your telomere age – it’s not surprising if this doesn’t change; even if you eliminated all senescent cells, and even if they all had very short telomeres, it’s still only a very tiny proportion of total cells, so the measured average telomere length will not change noticeably. Same goes for mtDNA age – I would not expect it to change much even if the DRI is 100% effective.

    It would be interesting, though, to look at markers for inflammation. In theory, eliminating senescent cells that have SAS phenotype should reduce general inflammation measurably; that’s where I’d expect the main benefit to arise. And of course that would be very significant.

    Good luck with your continued rejuvenation! I’ll be following your progress.



    1. hi, my inflammation (C-Reactive Protein) has been consistently low (except the Nov 8th/17 test).


      1. Have you tried GDF11 yet? See Steve Perry on Youtube.


  2. Hi mr darren i have been keeping up with the experiments that you have been doing and i am impressed , my grand parents are in a not so great situations ,and i want to try the foxo4-dri for them i was hoping that you can give me adresses to perchase the foxo4-dri and pointers on how thay could use and the ammount athat thye should use.
    Its not so that they can be youngsters but they both had different accidents and they just dont recover any more.regards


  3. Good to see you’re still updating the log!

    How is your eyesight? has the improvement you noticed in the beginning persisted? has it improved further?

    +1 to the inflammation marker research by the way.


    1. Hi, my prescription has been -1.75 Left eye, -1.5 Right eye for 30yrs.
      I ordered glasses about a week ago -1.25 Left, and -1.25 Right (hopefully, I didn’t go too optically optimistic).


      1. So how did the vision go with the new prescription, and how do you feel overall?

        I’m wondering if the FOX04-DRI is worth the investment, and if you believe you go the actual DRI form of it.


        1. I’ve been wearing my new 1.25, 1.25 lenses for a few weeks and they are good, I may try 1.5, 1.25 next time, but good enough for now. So my vision has improved at least .25 in both eyes. Hard to say now what is causing my continued improvements now– I’m doing a better diet/exercise and taking NMN and C60 Olive oil, among other supplements etc… my ‘rejuvenation’ (and this blog) is no longer a controlled experiment with just FOX04-dri.


          1. Myopia improves with age. Older people wear + glasses. I don’t want to spoil the party though.

  4. Have you tried GDF11 yet? Some of us are experimenting with that. Also, see Steve Perry on Youtube.


    1. Hi, I’ve tried GDF-11, and plan to get back to it again soon. Let us know pls your results.


      1. My hair is slowly turning brown again, from gray/white. I sleep better (5-6 hours straight often). My face looks better (younger) to me also. BP, RHR, and other biomarkers are great as well. I’m 60 yrs old. I’ve been taking GDF11 for about 8 months now.


  5. Hi, it has been a year and I was wondering if you have noticed anything new?
    Also I had seen something recently

    This could be another thing that could be self experimented with but seems that it would have very low risk. I wish I could try it myself but I would not be able to obtain the material in my location. I have seen cheap used Apheresis Machines but getting the tubes and IV bags would be impossible for me.

    Anyway I would love to hear a year later update on the FOX04-DRI if you can.

    Thank you


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